Application Example: Using a
protein SynaBASE and a nucleotide sequence, the nucleotide-protein
mining of the sequence reveals areas which potentially encode genic
Human cDNA clone BU185479.1 was queried against a
SynaBASE of SwissProt using SynaMine. Queries against SynaMine are
typically returned within 200 milliseconds.
assumption that the gene is translated, the SynaMine result
indicates sections in several frames of the gene that may encode for
protein domains or motifs.
Detailed analysis of keywords
suggests gene function based upon inference from predictability of
patterns using SwissProt data. In addition to matching these known
regions, additional new keywords are identified, which may suggest
potential new novel regions or domains. In this example, the
annotation suggests a role as a monoglyceride lipase, but SynaMine
also suggest roles as a hydrolase, lipase, esterase or